Does Ketoconazole Shampoo Work for Hair Loss?

There are hundreds, perhaps thousands of shampoo based treatments that claim produce hair growth. It is difficult to assess all of them and generalize them. Many ingredients are herbal such as He Shou Wu or Saw Palmetto, others contain chemical ingredients such as minoxidil (Rogaine), others are based on vitamins and minerals, and some even include antibiotics such as Ketoconazole. Each shampoo formula is unique and has different effects. While many substances have been studied, it is impossible to perform clinical trials on all the herbal and vitamin based products that become available.

A study was performed in Belgium and published in the prestigious Journal of Dermatology which measured the long term effects of Ketoconazole in Androgenic Alopecia. The study claims that genetic predisposition and the influence of androgens are beyond doubt, however they do not explain the presence of inflammatory cells on the transitional hair follicles. Histological observations show that there is a significant number of inflammatory cells on the hair follicle stem cells. This study enrolled a total of 39 men of which 27 were assigned to an exclusive Ketoconazole 2% shampoo (Nizoral), while 12 men used an unmedicated wash and go shampoo (Vidal Sassoon) with or without Minoxidil (Rogaine).

Ketoconazole is a well-known antifungal drug that is used to treat and prevent fungal skin infections. Commercially it is available as an antidandruff shampoo, topical cream, or in tablets. It is known to produce a certain anti-inflammatory effect. It has been tested in androgenic alopecia because it is active against Malassezia spp and Staphylococcus spp which are part of the scalp microflora.

Ketoconazole Shampoo for Hair Loss
Ketoconazole Shampoo for Hair Loss

This study concluded that there’s an unequivocable effect of a 2% Ketoconazole shampoo on hair follicles affected by Androgenic Alopecia. Hair density, size, and proportion of anagen follicles were all improved compared with the control group. The study concludes that the regular use of 2% Ketoconazole shampoo may participate to improve the presentation of Androgenic Alopecia. There was a significant reduction in inflammatory cells. Although the studies results are encouraging, it is noted that a further controlled study is necessary to confirm the findings in a larger group of patients.

More recent studies suggest that Ketoconazole has anti-inflammatory properties that can mend skin damage caused by Androgenic Alopecia, disrupt the production of dihydrotestosterone (DHT), and may even have a stimulating effect on hair growth.

That’s about chemical treatment for hair loss or a stimulating hair growth. If you looking for hair treatment with natural methods please visit a good article about best hair loss treatment in 2018 blog.

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